Necrotizing soft tissue infection refers to a bacterial infection that causes body tissue to die. The infection develops when the bacteria enters the body, usually through a minor cut or scrape. The bacteria begins to grow, releasing harmful substances (toxins) that kill tissue. The blood flow to the area is also affected. A very severe form of necrotizing soft tissue infection occurs due to the bacteria Streptococcus pyogenes, which is sometimes called “flesh-eating bacteria” or strep. Hyperbaric oxygen therapy is an FDA-approved treatment for cases of necrotizing soft tissue infection. It can fill the affected areas with oxygen, reduce systemic toxicity, and limit the spread and progression of infection. It can also enhance antibiotic treatment by amplifying the effects of antibiotics, enhancing the body’s natural ability to fight off bacteria, and in some cases directly killing the bacteria.